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Salcaprozate sodium(CAS 203787-91-1)
Salcaprozate sodium(CAS 203787-91-1), also known as SP-54 or Zonulin inhibitor, is a synthetic compound that acts as an antagonist of zonulin, a protein involved in the regulation of tight junctions between cells in the intestinal lining. It is a small molecule drug with the chemical formula C₃₀H₄₂N₆O₁₃S and a molecular weight of approximately 694.8 g/mol.
Products Description
Salcaprozate sodium (CAS 203787-91-1)
Salcaprozate sodium(CAS 203787-91-1), also known as SP-54 or Zonulin inhibitor, is a synthetic compound that acts as an antagonist of zonulin, a protein involved in the regulation of tight junctions between cells in the intestinal lining. It is a small molecule drug with the chemical formula C₃₀H₄₂N₆O₁₃S and a molecular weight of approximately 694.8 g/mol.
Chemical Specification
| Appearance : | White or of- white powder or crystlline power,odorless |
| CAS Number | 203787-91-1 |
| Physical State : | Solid |
| Purity: | ≥99% |
| Molecular Formula : | C15H20NNaO4 |
| Melting Point : | 152°C~156°C |
| Boiling Point : | 287-290° C |
| Molecular Weight | 301.31 |
| Description | Salcaprozate sodium (SNAC), an oral absorption promoter, and has the potential as a delivery agent for oral forms of heparin and insulin. Salcaprozate sodium (SNAC) could increase passive transcellular permeation across small intestinal epithelia based on increased lipophilicity arising from non-covalent macromolecule complexation |
Chemical Applications
Some of the potential applications of this compound include:
- Inflammatory Bowel Disease (IBD): Salcaprozate sodium has shown promise in preclinical studies and early clinical trials as a potential treatment for Crohn’s disease and ulcerative colitis, two types of IBD. By targeting zonulin and modulating intestinal permeability, it aims to reduce inflammation and improve symptoms associated with these conditions.
- Celiac Disease: it has been explored as a possible adjunct therapy for celiac disease, an autoimmune disorder triggered by gluten consumption. It may help in mitigating the effects of gluten exposure by minimizing the disruption of the intestinal barrier.
- Non-Alcoholic Fatty Liver Disease (NAFLD): Studies have suggested that increased intestinal permeability plays a role in the development and progression of NAFLD. Salcaprozate sodium could potentially be used to restore intestinal barrier function and reduce liver inflammation in this condition.
- Other Gastrointestinal Disorders: Salcaprozate sodium may have potential applications in other gastrointestinal disorders associated with increased intestinal permeability, such as irritable bowel syndrome (IBS) and food allergies.
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