Rocuronium Bromide

Product Description

Rocuronium bromide (CAS 119302-91-9) is a non-depolarizing neuromuscular blocking agent that is used in anesthesia to induce muscle relaxation and facilitate endotracheal intubation during surgical procedures. It belongs to the class of drugs known as aminosteroid neuromuscular blockers.

Rocuronium acts by competitively binding to the nicotinic acetylcholine receptors at the motor endplate of skeletal muscles, thereby preventing the action of acetylcholine and inhibiting neuromuscular transmission. This results in temporary paralysis of the skeletal muscles, allowing for easier insertion of a breathing tube into the trachea and ensuring optimal conditions for surgery.

Compared to other neuromuscular blocking agents, rocuronium has a rapid onset of action and intermediate duration of effect. It has a relatively short time to peak effect and a moderate duration of action, making it suitable for various surgical procedures. The duration of muscle relaxation can be reversed using medications such as neostigmine or sugammadex.

Rocuronium is typically administered intravenously and is commonly used in operating rooms, intensive care units, and emergency departments. The dosage and administration of rocuronium are determined by factors such as the patient’s weight, age, and clinical condition, as well as the desired level of muscle relaxation.

Chemical Applications

Rocuronium bromide (CAS 119302-91-9) is primarily used as a pharmaceutical agent in the field of anesthesia. Its main application is in facilitating muscle relaxation during surgical procedures. Here are some key applications of rocuronium bromide:

1. Anesthesia: Rocuronium bromide is commonly used as a neuromuscular blocking agent during general anesthesia. It is administered intravenously to induce muscle paralysis, allowing for endotracheal intubation and maintaining optimal conditions for surgery. Rocuronium provides temporary muscle relaxation, which aids in surgical access and prevents patient movement during procedures.
2. Endotracheal Intubation: Rocuronium bromide is particularly useful in facilitating endotracheal intubation, which involves inserting a tube into the trachea to establish a secure airway during anesthesia. The muscle relaxation induced by rocuronium allows for easier insertion of the breathing tube, ensuring proper oxygenation and ventilation.
3. Mechanical Ventilation: Rocuronium can be used to maintain muscle relaxation during mechanical ventilation in critically ill patients. This helps prevent patient-ventilator asynchrony and improves the effectiveness of ventilation.
4. Emergency Medicine: Rocuronium bromide may be used in emergency situations where rapid sequence intubation is necessary. It allows for swift and controlled intubation in critical conditions such as trauma, cardiac arrest, or respiratory failure.