HMPA (Hexamethylphosphoramide)

Product Description

HMPA (Hexamethylphosphoramide): HMPA is a polar aprotic solvent used in various chemical reactions, including organometallic chemistry and peptide synthesis.

Hexamethylphosphoramide (HMPA) is an organic compound with the chemical formula [(CH3)2N]3PO. It is a colorless to pale yellow liquid that has gained importance in the field of chemistry due to its unique properties and versatile applications. Here’s a more detailed description of HMPA:

1. Chemical Structure: HMPA has a phosphorus atom (P) at its center, bonded to three dimethylamino (-N(CH3)2) groups. This structure gives HMPA its distinct characteristics and makes it a polar aprotic solvent.
2. Physical Properties:
   • State: HMPA is typically found in a liquid state at room temperature.
   • Odor: It has a faint, ammonia-like odor.
   • Solubility: HMPA is highly soluble in a wide range of organic solvents but has limited solubility in water.
3. Unique Properties:
   • Polar Aprotic Solvent: HMPA is known for its polarity and ability to dissolve a wide variety of polar and nonpolar compounds. It is often used as a reaction medium in chemical synthesis, especially in reactions involving highly reactive or sensitive compounds.
   • High Boiling Point: It has a relatively high boiling point (approximately 232°C or 450°F), which makes it useful in high-temperature reactions.
   • Strong Solvation Properties: HMPA is an excellent solvating agent, meaning it can effectively dissolve and stabilize ions and highly polar molecules.
4. Applications:
   • Organometallic Chemistry: HMPA is commonly used in organometallic chemistry to solvate and stabilize highly reactive metal complexes and facilitate various reactions.
   • Peptide and Protein Synthesis: It is used in peptide and protein synthesis as a solvent and a reagent.
   • Extraction and Separation: HMPA is utilized in extraction and separation processes due to its ability to dissolve a wide range of organic and inorganic compounds.
   • Catalysis: It serves as a reaction medium in certain catalytic reactions.
   • Nuclear Magnetic Resonance (NMR) Spectroscopy: HMPA is used as a solvent for NMR spectroscopy, particularly for the study of certain compounds.
5. Safety Considerations:
   • HMPA is known to be absorbed through the skin, so precautions should be taken when handling it.
   • It may have toxic effects if ingested or absorbed in large quantities, and its use should be conducted in a well-ventilated laboratory environment.

In summary, Hexamethylphosphoramide (HMPA) is a valuable solvent in the field of chemistry due to its versatile properties, making it useful for a wide range of applications, especially in reactions involving sensitive compounds or organometallic complexes. Researchers and chemists carefully consider its unique characteristics when selecting solvents for specific chemical processes.

For more than 30 years,  Shandong Voyage Ocean Biotechnology  ’s expertise in chemical intermediate products is unrivaled. Our dedication to delivering high-quality solutions has earned  an excellent reputation in the industry. Partnering with us ensures access to a large and reliable supply of chemical intermediates, specialty raw materials, OLED materials and UV absorbers, organic intermediates, organic chemicals, pharmaceutical intermediates, pesticide intermediates, essence fragrances.

Get a quote or price,Let us know: Email Us:amy@voyageoceanbio.com,  Phone&Whatsapp :8613705364142